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Appropriate studies performed to date have not demonstrated pediatric-specific dose for patients receiving piperacillin and tazobactam combination. The usual adult dosage of ZOSYN for drip infusion is a 4.5 g single dose, four times daily. The usual pediatric dosage for intravenous infusion Piperacillin and tazobactam for injection, USP is indicated in adults and pediatric patients (2 months of age and older) for the treatment of nosocomial pneumonia (moderate to severe) caused by beta-lactamase producing isolates of Staphylococcus aureus and by piperacillin and tazobactam-susceptible Acinetobacter baumannii, Haemophilus Usual Pediatric Dose for Intraabdominal Infection. DOSE EXPRESSED AS PIPERACILLIN-TAZOBACTAM: 2 to 9 months: 90 mg/kg IV every 8 hours Older than 9 months: Up to 40 kg: 112.5 mg/kg IV every 8 hours; Greater than 40 kg: 3.375 g IV every 6 hours; DOSE EXPRESSED AS PIPERACILLIN: 2 to 9 months: 80 mg/kg (piperacillin component) IV every 8 hours phenadoz coupon Medscape – Indication-specific dosing for Zosyn, (piperacillin-tazobactam), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy lactation schedules, and Piperacillin-Tazobactam (Zosyn) 75 mg/kg (piperacillin) 3 g (piperacillin) 2.25 g vial (2 g piperacillin/0.25 g tazobactam) Reconstitute with 8 mL of NS = 30 min mg/mL piperacillin Vancomycin 15 mg/kg 1.5 g 500 mg vial Reconstitute with 60 min 8 Yes Max infusion rate = 1g /hr 10 mL of NS = 50 mg/mL
Recommended Dosage of ZOSYN for Pediatric Patients 2 months of Age and Older, Weighing up to 40 Kg and With Normal Renal Function Age Appendicitis and /or Peritonitis Nosocomial Pneumonia 2 months to 9 months. 90 mg/kg (80 mg piperacillin/10 mg tazobactam) every 8 (eight) hours 90 mg/kg (80 mg piperacillin/10 mg tazobactam) every 6 (six) hours For children with appendicitis and/or peritonitis 9 months of age or older, weighing up to 40 kg, and with normal renal function, the recommended ZOSYN dosage is 100 mg piperacillin/12.5 mg tazobactam per kilogram of body weight, every 8 hours.
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